Psoriasis skin and methods of treatment and causes
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Encyclopedia of skin diseases and reproductive
Psoriasis skin and methods of treatment and causes
Psoriasis:Is
a genetic disease characterized by proliferative inflammatory plaques
and clear edges are covered with silvery scales that appear mainly on
the extensor prominence and scalp. Psoriasis is rare in infants and is common in children and young age groups.Diaper psoriasis, which affects infants is usually classified under seborrheic dermatitis (a sebaceous) infantile.It was found that 5% of infants and children with diaper dermatitis, have the lesions of psoriasis later.
The pathogenesis:Different pathological changes occur in the lesions of psoriasis are:Increased cellular activity in the epidermis due to the rapid proliferation of skin cells.Increase peeling of the skin.Activity of the skin increases.Increase the blood vessels in the dermis.Increase the rate of protein synthesis by the skin.Psoriatic reaction is cellular and nuclear in the cells and the cell layer Almalbhristih Alhabibabh.
Reasons:The cause is unknown: it may be psoriasis and genetically as an autosomal dominant may be seen running in some families. There is evidence that genetics an autosomal dominant single gene with incomplete permeability abnormalities.In psoriatic lesions is the traditional cycle of keratinization as keratinocytes mature faster and reach the surface of the skin in a shorter time than normal.
Histopathology:Abnormal features in the pathogenesis of psoriasis include irregular epidermal proliferation and increased mitotic figures in keratinocytes, and the expansion of vascular and superficial impact Tikka (growing) lesions infiltration with leukocytes, including neutrophils, lymphocytes and monocytes and macrophages.The pathological changes are:Hyperkeratosis and parakeratosis.Epidermal hyperplasia.Acanthosis and papillomatosis.Infiltration on a large dilated capillary loops.In class Malpeghian neutrophils may accumulate to form the characteristic spongiform pustules of "Kogoj".
Predisposing factors:Bruises and injuries: Psoriasis at the site known as trauma (Koebner phenomenon), Wide range of injurious local stimuli, including physical, chemical, electrical, surgical, infective and inflammatory has proven to elicit psoriatic lesions or exacerbate pre-existing lesions.Infections: The role of streptococcal infection, especially in the throat, in provoking acute guttate psoriasis and this is what Evsar improvement of psoriatic lesions after taking antibiotics to treat infection of the tonsils and sore throat.Endocrine factors:Peaks of incidence at the age of puberty and menopause may explain the role of hormones ..Generalized pustular psoriasis may be predisposed to pregnancy and menstruation, high doses of estrogen.Rays of the sun:Although the sun is generally beneficial, but a small percentage of cases of psoriasis are raised by strong flares during the summer in the sun-exposed areas.Metabolic factors:Hypocalcemia (eg, after accidental parathyroidectomy) may precipitate psoriasis.Drugs:Lithium-blocking agents, beta blockers, Clonidine, potassium iodide, amiodarone, digoxin, antidepressants, antidepressants, trazodone, penicillin terfenadine grease and anti-malaria drug may be mixed Bartkas psoriasiform.Sudden stop of clobetasol systemically, such as strong topical steroid (corticosteroid, as well as propionate), is particularly associated with the spread of generalized pustular psoriasis.Exacerbating effect caused by NSAIDs such as oral phenylbutazone, oxyphenbutazone, indomethacin, diclofenac Miklovinamat isoprofen is well documented and leads to the spread of the disease.Psychological factors:Stress and emotional and psychological tensions may have a role in exacerbating psoriasis.
Clinical FeaturesIn early infancy and childhood may be similar to diaper dermatitis.Erythematous scaly or atopic dermatitis, where the differentiation between these lesions is not easy sometimes.Psoriasis is common in children, although very rare congenital psoriasis.Children and adults often have the guttate type of psoriasis, while older patients may develop different clinical forms and other forms of severe psoriasis such as erythrodermic and pustular types.
Different patterns of morphologicalPsoriasis VulgarisSkin lesions:The primary lesions are papular, scaly patches and covered with a clear border silvery adherent scales. Scrape the area with a glass slide leaves minute bleeding points (tag or mark Osbetz bleeding), which is diagnostic of psoriasis.This type of psoriasis presents with few lesions and non-itchy usually lashes.
Treatment of Psoriasis
Treatment of psoriasis treatments psoriasis treatments used for psoriasis someSome therapies used in psoriasis
Some therapies used in psoriasis1 - cortisoneAre described in the form of cortisone creams, ointments or lotions to control certain medical conditions. It must take some precautions when it is used in some sensitive areas such as the face - thigh - genital - as in the elbows - the scalp and elsewhere, and must follow the instructions of their doctor. In order to obtain the possibility of side effects of steroids such as reducing the thickness of the skin, swelling and skin color variation. The abrupt cessation of therapy may lead to disease outbreak and spread of new, it is possible that the disease becomes resistant to treatment after a period of time. Your doctor may inject into some areas that are difficult to treat, and this injection in limited quantities and very few in order to avoid getting side effects.2 - anthralinA good treatment for severe cases and thick patches of psoriasis, and may lead to irritation of the skin and change the color of the skin temporarily, but with the recent evolution of treatment has become possible to avoid these side effects3 - Vitamin DAnd disbursed through prescriptions, as the vitamin D found in drugstores and supermarkets, which is sold without a prescription does not help in the healing and treatment of psoriasis. According to this treatment of psoriasis, Ltd. in the body in addition to other treatments. The therapy is used in small amounts to avoid side effects4 - Ritnoidz RetinoidsIs a prescription vitamin A pomade is used in conjunction with topical steroid cream for the topical treatment of psoriasis. Should not be on pregnant women that use this treatment.5 - coal tar, coal tarIs used to treat areas that are difficult to treat psoriasis in which treatment is.6 - treatment Jokkerman Goeckerman TreatmentIs the use of liquid coal tar with ultraviolet radiation for the treatment of severe cases of psoriasis. This treatment is being into the specialized medical centers.7 - photodynamic therapy: It may be the light of the sun and ultraviolet rays are useful for the treatment of psoriasis, which affects all areas of the body, which take place under medical supervision and in specialized centers for this treatment. Should consult a doctor before exposure to natural sunlight exposure to prevent complications.8 - PUVA PuvaTo natural sunlight exposure to prevent complications. PUVA Puva: PUVA therapy is effective for rate of 85-90% of cases of psoriasis, and this treatment is used when psoriasis is not responding to other treatments and spread. Is to give the patient a drug called (Psoralen) and psoralen is then exposed to limited amounts of ultraviolet radiation may be the work of about 25 treatment session over a two or three months to start to get results.
* Some medicines that cause an increase in the psoriasisMedicine is often described in- Beta - blockers e.g. propranolol, atenolol - hypertension - Allenbhh thoracic- Non - steroidal anti-inflammatory drugs e.g. indomethacin. Naproxen - arthritis - such as general pain and dental pain Althellb- Lithium - psychological symptoms such as depression and mania- Chloroquine - malaria and some skin diseases such as lichen and sun sensitivity
The pathogenesis:Different pathological changes occur in the lesions of psoriasis are:Increased cellular activity in the epidermis due to the rapid proliferation of skin cells.Increase peeling of the skin.Activity of the skin increases.Increase the blood vessels in the dermis.Increase the rate of protein synthesis by the skin.Psoriatic reaction is cellular and nuclear in the cells and the cell layer Almalbhristih Alhabibabh.
Reasons:The cause is unknown: it may be psoriasis and genetically as an autosomal dominant may be seen running in some families. There is evidence that genetics an autosomal dominant single gene with incomplete permeability abnormalities.In psoriatic lesions is the traditional cycle of keratinization as keratinocytes mature faster and reach the surface of the skin in a shorter time than normal.
Histopathology:Abnormal features in the pathogenesis of psoriasis include irregular epidermal proliferation and increased mitotic figures in keratinocytes, and the expansion of vascular and superficial impact Tikka (growing) lesions infiltration with leukocytes, including neutrophils, lymphocytes and monocytes and macrophages.The pathological changes are:Hyperkeratosis and parakeratosis.Epidermal hyperplasia.Acanthosis and papillomatosis.Infiltration on a large dilated capillary loops.In class Malpeghian neutrophils may accumulate to form the characteristic spongiform pustules of "Kogoj".
Predisposing factors:Bruises and injuries: Psoriasis at the site known as trauma (Koebner phenomenon), Wide range of injurious local stimuli, including physical, chemical, electrical, surgical, infective and inflammatory has proven to elicit psoriatic lesions or exacerbate pre-existing lesions.Infections: The role of streptococcal infection, especially in the throat, in provoking acute guttate psoriasis and this is what Evsar improvement of psoriatic lesions after taking antibiotics to treat infection of the tonsils and sore throat.Endocrine factors:Peaks of incidence at the age of puberty and menopause may explain the role of hormones ..Generalized pustular psoriasis may be predisposed to pregnancy and menstruation, high doses of estrogen.Rays of the sun:Although the sun is generally beneficial, but a small percentage of cases of psoriasis are raised by strong flares during the summer in the sun-exposed areas.Metabolic factors:Hypocalcemia (eg, after accidental parathyroidectomy) may precipitate psoriasis.Drugs:Lithium-blocking agents, beta blockers, Clonidine, potassium iodide, amiodarone, digoxin, antidepressants, antidepressants, trazodone, penicillin terfenadine grease and anti-malaria drug may be mixed Bartkas psoriasiform.Sudden stop of clobetasol systemically, such as strong topical steroid (corticosteroid, as well as propionate), is particularly associated with the spread of generalized pustular psoriasis.Exacerbating effect caused by NSAIDs such as oral phenylbutazone, oxyphenbutazone, indomethacin, diclofenac Miklovinamat isoprofen is well documented and leads to the spread of the disease.Psychological factors:Stress and emotional and psychological tensions may have a role in exacerbating psoriasis.
Clinical FeaturesIn early infancy and childhood may be similar to diaper dermatitis.Erythematous scaly or atopic dermatitis, where the differentiation between these lesions is not easy sometimes.Psoriasis is common in children, although very rare congenital psoriasis.Children and adults often have the guttate type of psoriasis, while older patients may develop different clinical forms and other forms of severe psoriasis such as erythrodermic and pustular types.
Different patterns of morphologicalPsoriasis VulgarisSkin lesions:The primary lesions are papular, scaly patches and covered with a clear border silvery adherent scales. Scrape the area with a glass slide leaves minute bleeding points (tag or mark Osbetz bleeding), which is diagnostic of psoriasis.This type of psoriasis presents with few lesions and non-itchy usually lashes.
Treatment of Psoriasis
Treatment of psoriasis treatments psoriasis treatments used for psoriasis someSome therapies used in psoriasis
Some therapies used in psoriasis1 - cortisoneAre described in the form of cortisone creams, ointments or lotions to control certain medical conditions. It must take some precautions when it is used in some sensitive areas such as the face - thigh - genital - as in the elbows - the scalp and elsewhere, and must follow the instructions of their doctor. In order to obtain the possibility of side effects of steroids such as reducing the thickness of the skin, swelling and skin color variation. The abrupt cessation of therapy may lead to disease outbreak and spread of new, it is possible that the disease becomes resistant to treatment after a period of time. Your doctor may inject into some areas that are difficult to treat, and this injection in limited quantities and very few in order to avoid getting side effects.2 - anthralinA good treatment for severe cases and thick patches of psoriasis, and may lead to irritation of the skin and change the color of the skin temporarily, but with the recent evolution of treatment has become possible to avoid these side effects3 - Vitamin DAnd disbursed through prescriptions, as the vitamin D found in drugstores and supermarkets, which is sold without a prescription does not help in the healing and treatment of psoriasis. According to this treatment of psoriasis, Ltd. in the body in addition to other treatments. The therapy is used in small amounts to avoid side effects4 - Ritnoidz RetinoidsIs a prescription vitamin A pomade is used in conjunction with topical steroid cream for the topical treatment of psoriasis. Should not be on pregnant women that use this treatment.5 - coal tar, coal tarIs used to treat areas that are difficult to treat psoriasis in which treatment is.6 - treatment Jokkerman Goeckerman TreatmentIs the use of liquid coal tar with ultraviolet radiation for the treatment of severe cases of psoriasis. This treatment is being into the specialized medical centers.7 - photodynamic therapy: It may be the light of the sun and ultraviolet rays are useful for the treatment of psoriasis, which affects all areas of the body, which take place under medical supervision and in specialized centers for this treatment. Should consult a doctor before exposure to natural sunlight exposure to prevent complications.8 - PUVA PuvaTo natural sunlight exposure to prevent complications. PUVA Puva: PUVA therapy is effective for rate of 85-90% of cases of psoriasis, and this treatment is used when psoriasis is not responding to other treatments and spread. Is to give the patient a drug called (Psoralen) and psoralen is then exposed to limited amounts of ultraviolet radiation may be the work of about 25 treatment session over a two or three months to start to get results.
* Some medicines that cause an increase in the psoriasisMedicine is often described in- Beta - blockers e.g. propranolol, atenolol - hypertension - Allenbhh thoracic- Non - steroidal anti-inflammatory drugs e.g. indomethacin. Naproxen - arthritis - such as general pain and dental pain Althellb- Lithium - psychological symptoms such as depression and mania- Chloroquine - malaria and some skin diseases such as lichen and sun sensitivity
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